Induction of mammary adenocarcinomas by medroxyprogesterone acetate in BALB/c female mice |
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Authors: | C Lanari A A Molinolo C D Pasqualini |
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Affiliation: | 1. Department of Psychiatry & Human Behavior School of Medicine, University of California Irvine, Irvine, CA, USA;2. Clinical Development, Alkermes, Inc., Waltham, MA, USA;3. Clinical Development and Medical Affairs, Alkermes, Inc., Waltham, MA, USA |
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Abstract: | In a previous paper we reported that medroxyprogesterone acetate (MPA) decreased the incidence of foreign body tumorigenesis in BALB/c mice but that mammary adenocarcinomas appeared in some of the females. The experiment was repeated in 245 virgin females as follows: (1) 40 mice treated with 40 mg of MPA depot s.c. every 2 months during a whole year; (2) 117 mice bearing a foreign body (FB) and treated with MPA; (3) 46 mice bearing a FB; (4) 42 non-treated mice. Mammary adenocarcinomas developed in 16/40 in group 1 and 30/117 in group 2; no mammary tumors appeared in either control groups. The tumors were infiltrating adenocarcinomas often affecting more than one mammary gland; metastases were occasionally observed. Animals killed after 1 year of MPA treatment presented deciduomas. MPA also decreased the incidence of FB-induced sarcomas, confirming previous results. |
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