Highly Polymorphic Domains of the Human Serum Amyloid A (SAA) Gene GSAA1 |
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| Authors: | GH SACK JR CC TALBOT JR |
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| Institution: | Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. |
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| Abstract: | The DNA of the human serum amyloid A (SAA) gene GSAA1 contains several repetitive regions within its introns. We have studied length variations at one such region in the 2nd intron by selective amplification using the polymerase chain reaction (PCR) and defined oligonucleotide primers. The lengths of the repetitive regions frequently differ between individual chromosomes and can be transmitted as Mendelian markers, making them useful for genetic linkage analysis. |
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