| 淋病奈瑟菌耐药性与耐药基因的研究进展 |
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| 引用本文： | 刘蓉华. 淋病奈瑟菌耐药性与耐药基因的研究进展[J]. 医学综述, 2011, 17(13): 2024-2026 |
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| 作者姓名： | 刘蓉华 |
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| 作者单位： | 云南大理学院基础医学院病原生物学综合实验室,云南,大理,671000 |
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| 基金项目： | 云南省科技厅科学研究基金 |
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| 摘 要： | 随着抗生素的广泛使用,淋病奈瑟菌对常用的抗生素产生了不同程度的耐药。现综述近年淋病奈瑟菌的耐药性及耐药基因的研究进展,包括:改变PBPs的胞内作用靶位,导致对青霉素类抗生素的耐药,gyrA基因、parC基因和norm基因的突变,导致对氟喹诺酮类抗生素的耐药,药物外排机制引起多重抗生素的通透性降低,teM-1基因和tetM基因编码的胞质蛋白抑制了四环素类药物对细菌的毒性作用,阿奇霉素和大观霉素耐药与作用靶位的改变等。
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| 关 键 词： | 淋病奈瑟菌 耐药性 耐药基因 |
Recent Research Progress of Drug Resistance of Neisseria Gonorrhoeae and Resistance Genes |
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| LIU Rong-hua. Recent Research Progress of Drug Resistance of Neisseria Gonorrhoeae and Resistance Genes[J]. Medical Recapitulate, 2011, 17(13): 2024-2026 |
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| Authors: | LIU Rong-hua |
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| Affiliation: | LIU Rong-hua,ZHANG Lei.(General Laboratory of Pathogenic Biology,Faculty of Preclinical Medicine,Dali University,Dali 671000,China) |
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| Abstract: | Neisseria gonorrhoeae has presented different degrees of resistance to the commonly used antibiotics due to the widely use of antibiotics.Here is to review the main mechanisms of drug resistance of Neisseria gonorrhoeae and the research advances of drug resistance genes,mainly including:alteration of PBPs intracellularaction target resulting in the resistence to antibiotics such as penicillin;drug resistance to quinolone and the relation with gyrA,parC and norm gene mutation;the multiple transferable resis... |
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| Keywords: | Neisseria gonorrhoeae Drug resistance Drug resistance genes |
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