A new cytotoxic acyclic diterpene fromCarpesium divaricatum |
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| Authors: | Ok Pyo Zee Dae Keun Kim Sang Un Choi Chong Ock Lee Kang Ro Lee |
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| Institution: | Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwan University, Suwon, Korea. |
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| Abstract: | A new acyclic diterpene (1) and a known acyclic diterpene, 12(S)-hydroxygeranylgeraniol (2) were isolated from the aerial parts of Carpesium divaricatum. The structure of 1 was determined to be (2E,10E)-1,12-dihydroxy-18-acetoxy-3,7,15-trimethylhexadeca- 2,10,14-triene (1) on the basis of spectroscopic studies. Compounds 1 and 2 exhibited cytotoxicity against cultured human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15, with ED50 values ranging from 4.3-10.2 micrograms/ml and 4.1-8.3 micrograms/ml, respectively. |
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| Keywords: | Carpesium divaricatum Acyclic diterpene Cytotoxicity |
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