重症肝炎患者血清内源性一氧化氮水平及意义

目的　研究重型肝炎时内源性一氧化氮 (NO)产生水平及其临床意义。方法　对 74例重症肝炎患者血清NO、肿瘤坏死因子 (TNF)、内毒素 (LPS)水平进行了检测 ,并分析其临床意义。结果　各型重型肝炎患者TNF、ET水平显著升高 ,急性重肝、亚急性重肝患者NO水平呈现高、低两种状态 ,其中NO低水平组死亡率显著增高 (P <0 .0 5 )。慢重肝患者NO水平较低。结论　重型肝炎的急性炎症期NO产生增多可能对患者有益。

Endogenous nitric oxide levels and it s significance in the patients with gravis hepatitis

Objective To study levels of the endogenous nitric oxide (NO) and its significance in the patients with gravis hepatitis. Methodes The serum levels of NO, tumor necrosis factors(TNF) and lipopolysaccharides(LPS) was measured in 76 cases patients with every type gravis hepatitis, and its clinical significance were analysised. Results The results indicated serum levels of TNF and LPS were higher significenthy in all patients, but NO levels appeared high or low in the patients with acute and subacute gravis hepatitis. The fatality rate in patieat with the low NO group was obviously higher than that in the high NO group(P<0.05). The serum NO levels in the chronic gravis hepatitis groups was lower than other groups. Conclusion NO might be benefit to the patients with gravis hepatitis during acute inflammation.