胃癌患者血清VEGF水平与T淋巴细胞嗜银蛋白含量的相关性及临床意义

目的检测胃癌患者血清血管内皮生长因子(VEGF)水平和外周血T淋巴细胞嗜银蛋白(Ag-NORs)含量,探讨二者间的相关性及临床意义。方法采用酶联免疫双抗夹心法(ELISA)定量检测74例胃癌患者和32例健康人血清VEGF水平,同时检测外周血T淋巴细胞嗜银蛋白含量并进行相关分析。结果胃癌患者血清VEGF水平(383.33±121.67)pg/ml明显高于健康人(142.86±71.29)pg/ml(P<0.01),其水平与肿瘤大小、浸润深度、分化程度、有无转移、TNM分期有关(P<0.05或0.01);而胃癌患者外周血T淋巴细胞Ag-NORs含量(4.30±1.21)%明显低于健康人(7.65±1.38)%(P<0.01),其含量与胃癌分化程度、有无转移、TNM分期有关(P<0.05或0.01)。胃癌患者血清VEGF水平与外周血T淋巴细胞嗜银蛋白含量呈显著负相关(r=-0.659,P<0.01)。结论胃癌患者血清VEGF水平和外周血T淋巴细胞Ag-NORs含量是评估胃癌恶性生物学行为的重要指标。二者密切相关,对评价机体肿瘤免疫功能具有重要的临床参考价值。

Clinical Implication and Relationship between Serum Level of Vascular Endothelial Growth Factor and Content of T Lymphocytes Ag-NORs in Gastric Carcinoma

Objective To detect and explore the clinical implication and relationship between the serum level of vascular endothelial growth factor(VEGF) and content of T lymphocytes Ag-NORs in gastric carcinoma.Methods The serum level of VEGF in 74 patients with gastric carcinoma and 32 healthy persons was measured with the methods of ELISA.At the same time,the content of T lymphocytes Ag-NORs was detected correspondingly.Results The serum level of VEGF in patients with gastric carcinoma((383.33)±(121.67))pg/ml was si...