阿魏酸钠联合贝那普利治疗早期糖尿病肾病的疗效研究

目的 探讨阿魏酸钠(SF)联合贝那普利治疗早期糖尿病肾病(DN)的临床疗效.方法 将102例早期DN患者随机分成对照组(51例)和治疗组(51例),对照组在给予常规饮食、运动疗法和药物治疗的基础上给予贝那普利150 mg/次,口服,1次/d.治疗组在对照组治疗的基础上加用阿魏酸钠注射液0.3 g+生理盐水100 mL静脉滴注,1次/d,2 w为1个疗程,每个疗程间隔2 d,两组患者均治疗4个疗程.观察、记录治疗前后24 h尿微量白蛋白(UAER)、空腹血糖(FBG)、血尿素氮(BUN)、肌酐(Scr)、总胆固醇(TC)、甘油三酯(TG)和药物的不良反应.结果 对照组总有效率为76.47%,治疗组总有效率为90.20%,治疗组临床疗效优于对照组,差异有统计学意义(P<0.05).对照组治疗后UAER、Scr、TC较治疗前下降,治疗组治疗后UAER、FBG、BUN、Scr、TG低于治疗前,差异有统计学意义(P<0.05),且治疗组治疗后UAER、FBG、Scr、TG、TC低于对照组,差异有统计学意义(P<0.05).两组不良反应发生率差异无统计学意义(χ2=0.435,P=0.510).结论 阿魏酸钠注射液联合贝那普利治疗早期DN能显著降低尿微量白蛋白和血脂水平,改善微循环,减轻肾脏损害,延缓DN的发展,两药联合使用无明显不良反应.

The effects of benazepril associated with sodium ferulate injection on early diabetic nephropathy

Objective To investigate the effects and mechanisms of the combined use of benazepril and sodium ferulate injection for treatment of early diabetic nephropathy(DN).Methods One huandred and two cases of early DN patients were randomly divided into 2 groups.In the control group(n=51),the patients were received benazepril 100 mg/d,while in the experiment group(n=51) received benazepril 100 mg/d asoociated with sodium ferulate 0.3 g added in 0.9% solution of sodium ehoride 100 mL together driped by vein,qd.2 weeks was one treatment course,there was 2 day′s intermission.All treatment courses lasted 4 in both groups.urinary albumin excretion rate(UAER),fasting blood glucose(FBG),blood urea nitrogen(BUN),serum creatinine(Scr),triglyeride(TG),total cholesterol(TC) were deteded for all patients before and after therapy.The data obtained from two groups were compared each other and analysed statistically.Results The total effective rate of the control group was 76.47%,the total effective rate of the treatment group was 90.20%,the clinical curative effect of the treatment group was better than control group,the difference was statistically significant(P<0.05).In control group,after treatment,endogenous creatinine clearance rate(Scr),urinary albumin excretion rate(UAER),total cholesterol(TC) was lower than that was before treatment.In the treatment group,after treatment,UAER,FBG,BUN,Scr,TG were lower than before treatment,the difference was statistically significant(P<0.05).UAER,FBG,Scr,TG,TC of the treatment group were lower than those of the control group after therapy,the difference was statistically significant(P<0.05).Two groups of adverse reaction rate after the comparative difference was no statistically significant(χ2=0.435,P=0.510).Conclusion Combination of benazepril and sodium femlate injection with conventional western medication has a better effect on the treatment of early DN than only benazepril with conventional western medication.