不同类型冠心病患者微量白蛋白尿水平变化的研究

目的:本实验通过观察不同类型冠心病患者微量白蛋白尿水平,探讨微量白蛋白尿与冠心病及冠脉病变严重程度的关系.方法:选择接受冠脉造影检查的患者168例,依据冠脉造影结果分为冠心病组125例,对照组43例,测定患者微量白蛋白尿水平.结果:①冠心病组24 h尿白蛋白排泄率高于对照组(P＜0.05).②单支病变组、双支病变组、3支病变组均高于对照组(P＜0.05),3支病变组高于单支病变组、双支病变组(P＜0.05),双支病变组与单支病变组之间无差异(P =0.074).③UAP、AMI均高于对照组；AMI高于SAP、UAP,UAP高于SAP(P＜ 0.05),SAP与对照组无差异(P=0.446).④冠心病患者UAER值与冠脉病变Gensini总积分经Spearman相关分析呈正相关(rs=0.660,P＜0.05).结论:冠心病患者尿微量白蛋白水平较对照组高,且随冠脉病变程度增加而增加,与冠心病密切相关.

The Variation of Minimum Protein Levels in Urine of Coronary Heart Disease Patients

Objective:To observe the levels of microalbuminuria in patients with coronary artery disease,and to explore the relationship between microalbuminuria and coronary heart disease.Methods:According to the results of coronary angiography,125 patients with CHD were enrolled as CHD group and 43 patients with non-CHD as control group.Microalbuminuria was measured.Results:①The urinary albumin of CHD group was significantly higher than that in control group(P<0.05);②The urinary albumin level in CHD patients with 3 branch pathological changes was higher than in CHD patients with 1 branch pathological change(P<0.05)and in CHD patients with 2 branch pathological changes(P<0.05);③ UAP and AMI was significantly higher in CHD group than in control group(P<0.05);④Correlation analysis showed that the levels of microalbuminuria are positively correlated with Gensini scoring of coronary arterial lesions(P<0.05).Conclusion:The levels of microalbuminuria are closely correlated with the serious degree of coronary heart disease.