| 腺嘌呤制作慢性肾功能衰竭大鼠疾病模型 |
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| 引用本文： | 周静,爱民,王朝阳,李兰城.腺嘌呤制作慢性肾功能衰竭大鼠疾病模型[J].内蒙古医学院学报,2004,26(4):248-249,253. |
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| 作者姓名： | 周静 爱民 王朝阳 李兰城 |
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| 作者单位： | 1. 内蒙古医学院,药理教研室,内蒙古,呼和浩特,010059
2. 内蒙古医学院第一附属医院 |
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| 摘 要： | 目的：制作腺嘌呤致慢性肾功能衰竭大鼠疾病模型。方珐：Wistar大鼠腺嘌呤200mg／kg灌胃，1次／d，连续24d。观察大鼠一般状态的改变，检测血液，生化学指标(RBC、HGB、HCT、BUN、Set、Ca^2 、P^5 )，肾脏病理组织学检查。结果：模型出现RBC、HGB、HCT降低，BUN、Scr升高，低钙高磷，慢性肾功能衰竭主要血生化改变。肾脏病理组织学以肾小管损害为主。结论：腺嘌呤可以制作较理想的慢性肾功能衰竭大鼠疾病模型。
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| 关 键 词： | 腺嘌呤 慢性肾功能衰竭 疾病模型 |
| 文章编号： | 1004-2113(2004)04-0248-03 |
DISEASE MODEL OF CHRONIC RENAL FAILURE IN RATS MADE BY ADENINE |
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| ZHOU Jing,AI Min,WANG Zhao-yang.DISEASE MODEL OF CHRONIC RENAL FAILURE IN RATS MADE BY ADENINE[J].Acta Academiae Medicinae Neimongol,2004,26(4):248-249,253. |
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| Authors: | ZHOU Jing AI Min WANG Zhao-yang |
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| Abstract: | Objective: To make disease model of chronic renal failure (CRF) in rats by adenine. Methods: We fed the Wistar rats 200 mg/kg adenine per day and kept feeding them with the same dosage for 24 days. We observed the general health conditions and tested hematologic and biochemical indices (RBC, HGB, HCT, BUN, Scr, Ca 2+, P 5+) and changes in histopathology. Results: The disease model had the CRF symptoms of reduced levels of RBC, HGB, HCT, Ca 2+ and increased levels of BUN, Scr and P 5+. In histopathology, the disease model had main damage in renal tubules. Conclusion: The adenine was suitable for making disease model of CRF in rats. |
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| Keywords: | adenine chronic renal failure disease model |
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