卡介苗辅助治疗口腔颌面部恶性黑色素瘤初步报道

恶性黑色素瘤是恶性程度较高，治疗效果较差的一种肿瘤，该瘤细胞具有抗原性，与免疫有关，卡介苗(BCG)能提高机体免疫机制及抗癌能力，作者应用冷冻加手术治疗口腔颌面部恶性黑色素瘤42例，其中11例加用BCG免疫治疗。结果：加BCG组的中位生存时间为4年，3、5、7年的生存率分别为90%、72%、32%，8年以上为18%．而未用BCG组的中位生存时间为2年，3、5、7年生存率分别为55％、24%、12%，8年以上为3%，二组比较，BCG组生存时间明显延长，初步提示，BCG辅助治疗恶性黑色素瘤能减少复发或转移，延长病人的生存时间。

A preliminary study of BCG adjuvant therapy in oral and maxillofacial malignant melanoma.]

Malignant melanoma is a kind of tumor with higher malignant and lower therapeutic effect.it is demonstrated by experiment that melanoma cells have antigenicity and refer to immunology.BCG is a kind of biologic response modifier(BRM).it is able to promote physical antitumor ability.There were 42 patients with oral and maxillofacial malignant melanoma who received freezing therapy and surgery in this paper.11 cases of them added BCG immunotherapy.The result is that the median survival time of therapy plus BCG group is 4 years,and 3 years,5 years,7 years survival rate are 89%,72% and 32%,over 8 years survival rate is 18%.The median survival time of another group is 2 years,and 3 years,5 years,7 years survival rate are 55%,24% and 12%,over 8 years survival rate is 3%.There is a statistically significant difference between these two groups and BCG group has a longer survival time.This preliminary study demonstrated that BCG adjuvant therapy could decrease recurrence of metastases and increase patients survival time.