Evaluation of susceptibility patterns and BRO β-lactamase types among clinical isolates of Moraxella catarrhalis |
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Authors: | D. Esel Y. Ay-Altintop G. Yagmur S. Gokahmetoglu B. Sumerkan |
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Affiliation: | Department of Microbiology and Clinical Microbiology, Erciyes University Faculty of Medicine, Kayseri, Turkey. eseld@erciyes.edu.tr |
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Abstract: | The aims of this study were to detect BRO beta-lactamase types and to evaluate any correlation with the susceptibility patterns of 90 clinical isolates of Moraxella catarrhalis. The overall prevalences of the bro-1 and bro-2 genes were 78% and 12%, respectively. Penicillin G MICs for BRO-1+ isolates were significantly higher than those for BRO-2+ isolates. All the isolates were susceptible to amoxycillin-clavulanate, levofloxacin and cefixime. Resistance to clarithromycin, tetracycline and trimethoprim-sulphamethoxazole was 1.1%, 2.2% and 1.1%, respectively. One-step, length-based PCR was an efficient method to screen for BRO beta-lactamase genes. |
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Keywords: | Antibiotic susceptibility β-lactamase BRO Moraxella catarrhalis PCR resistance |
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