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Preclinical Imaging of Therapy Response Using Metabolic and Apoptosis Molecular Imaging

Authors:	Marijke De Saint-Hubert Huijun Wang Ellen Devos Kathleen Vunckx Lin Zhou Chris Reutelingsperger Alfons Verbruggen Luc Mortelmans Yicheng Ni Felix M Mottaghy

Institution:	1.Department of Nuclear Medicine,University Hospital Gasthuisberg Leuven,Leuven,Belgium;2.Department of Radiology,University Hospital Gasthuisberg Leuven,Leuven,Belgium;3.Laboratory for Radiopharmacy, K.U. Leuven, O&N 2,Leuven,Belgium;4.Department of Biochemistry,University Maastricht,Maastricht,Netherlands;5.Klinik für Nuklearmedizin,Universit?tsklinikum der RWTH Aachen,Aachen,Germany;6.Department of Nuclear Medicine,Maastricht University Medical Centre,Maastricht,The Netherlands

Abstract:	Purpose Early after therapy, 2-deoxy-2-¹⁸F]fluoro-d-glucose (¹⁸F]FDG) imaging is not always reliable due to the influx of inflammatory cells while apoptosis imaging offers a direct and early measurement of therapy effects. This study uses an improved apoptosis probe (^99mTc-hAnxA5) in combination with ¹⁸F]FDG imaging to evaluate therapy response.

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