| 下肢ASO患者血管腔内治疗前后血浆NPY的动态变化 |
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| 引用本文： | 高志伟,张皓,张柏根. 下肢ASO患者血管腔内治疗前后血浆NPY的动态变化[J]. 上海交通大学学报(医学版), 2008, 28(11) |
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| 作者姓名： | 高志伟 张皓 张柏根 |
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| 作者单位： | 上海交通大学医学院仁济医院血管外科,上海200127 |
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| 摘 要： | 目的 研究下肢动脉硬化性闭塞症(ASO)患者血管腔内治疗前后血浆神经肽Y(NPY)水平的动态变化.方法 采用放射免疫法检测13例下肢ASO患者(ASO组)接受血管腔内治疗前和治疗后不同时间点(即刻和第1、3、5 d)的血浆NPY水平,以15名健康体检者作为正常对照(对照组).比较血管腔内治疗前与治疗后第3天时患肢踝/肱指数(ABI)和ASO临床分期.结果 ASO组治疗前血浆NPY水平显著高于对照组,为(250.67±88.27)pg/mL us(168.40±64.64)Pg/mL,两组间比较差异有统计学意义(P<0.05);ASO组治疗后即刻的血浆NPY水平升达峰值,为(307.21±103.75)pg/mL,随后逐渐降低.治疗后第3天患肢ABl较治疗前显著升高(0.81±0.19 us 0.45±0.17),差异有统计学意义(P<0.01),同时ASO临床分期明显改善.结论 ASO患者血浆NPY在严重缺血状态下释放增加,治疗后随着患肢缺血状态的纠正(ABI升高)及临床症状的好转,血浆NPY水平逐渐下降接近正常水平.
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| 关 键 词： | 神经肽Y 动脉硬化性闭塞症 踝/肱指数 血管腔内治疗 |
Dynamic changes of plasma NPY before and after vascular intracavitary therapy in patients with lower extremity ASO |
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| GAO Zhi-wei,ZHANG Hao,ZHANG Bai-gen. Dynamic changes of plasma NPY before and after vascular intracavitary therapy in patients with lower extremity ASO[J]. Journal of Shanghai Jiaotong University:Medical Science, 2008, 28(11) |
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| Authors: | GAO Zhi-wei ZHANG Hao ZHANG Bai-gen |
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| Affiliation: | Department of Vascular Surgery;Renji Hospital;School of Medicine;Shanghai Jiaotong University;Shanghai 200127;China |
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| Abstract: | Objective To dynamically observe the concentrations of plasma neuropeptide Y(NPY)in the patients with lower extremity arteriosclerosis obliterans(ASO)before and after vascular interventional therapy.Methods The levels of plasma NPY were detected by radioimmunoassay in 13 patients with lower extremity ASO(ASO group)before vascular intracavitary therapy and immediately,1 d,3 d and 5 d after vascular intracavitary therapy.Meanwhile,15 healthy subjects were served as control group.Besides,the ankle-brachial ind... |
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| Keywords: | neuropeptide Y arteriosclerosis obliterans ankle-brachial index vascular intracavitary therapy |
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