| 镉砷接触工人肾功能损伤研究 |
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| 引用本文： | 洪峰,金泰廙,卢国栋,殷征宇. 镉砷接触工人肾功能损伤研究[J]. 中华劳动卫生职业病杂志, 2003, 21(6): 432-436 |
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| 作者姓名： | 洪峰 金泰廙 卢国栋 殷征宇 |
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| 作者单位： | 200032,上海,复旦大学公共卫生学院劳动卫生教研室 |
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| 基金项目： | 欧共体INCO DC项目基金资助项目 (ERB3 5 14PL9714 3 0 ) |
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| 摘 要： | 目的 探讨镉、砷对作业工人肾功能的联合作用。方法 以我国中南某厂镉、砷作业工人 114名为本研究的职业接触对象。以尿镉 (UCd)、尿砷 (UAs)作为接触标志物 ,尿 β2 微球蛋白(Uβ2 MG)、尿白蛋白 (UALB)、尿N 乙酰 β D 氨基葡萄糖苷酶 (UNAG)作为镉、砷致肾小管和肾小球损害的效应标志物。结果 UCd、UAs水平与Uβ2 MG、UALB、UNAG水平间均为正相关 ,具有明显的剂量-效应关系 (P <0 .0 5 ,P <0 .0 1)。结论 镉、砷对作业工人肾脏功能的联合作用主要表现为相加作用。
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| 关 键 词： | 镉砷 接触工人 肾功能损伤 职业接触 |
| 修稿时间： | 2002-12-09 |
Renal dysfunction in workers exposed to arsenic and cadmium |
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| HONG Feng,JIN Tai-yi,LU Guo-dong,YIN Zheng-yu. Renal dysfunction in workers exposed to arsenic and cadmium[J]. Chinese journal of industrial hygiene and occupational diseases, 2003, 21(6): 432-436 |
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| Authors: | HONG Feng JIN Tai-yi LU Guo-dong YIN Zheng-yu |
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| Affiliation: | Department of Occupational Health & Toxicology, School of Public Health, Fudan University, Shanghai 200032, China. |
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| Abstract: | OBJECTIVE: To examine the nephrotoxicity induced caused by combined effect of arsenic and cadmium in exposed workers. METHODS: Urinary cadmium and arsenic were used as the exposure biomarkers of cadmium and arsenic. Urinary beta2-microglobulin (Ubeta2-MG), albumin (UALB) and N-acetyl-beta-D-glucosaminidase (UNAG) were measured as the effective biomarkers of tubular and glomerular dysfunction induced by cadmium and arsenic. RESULTS: The combination of cadmium and arsenic induced more severe renal injury than that caused by either of the chemicals given alone. There were positive correlations and significant dose-effect among the concentrations of urinary cadmium, arsenic and levels of Ubeta2-MG, UALB, UNAG (P<0.05, P<0.01). CONCLUSION: Cadmium combined with arsenic may have additive effect on renal dysfunction in workers exposed to arsenic and cadmium. |
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| Keywords: | Cadmium Arsenic |
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