| 催产素调控焦虑情绪及其行为的神经生物学机制研究进展 |
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| 引用本文： | 李雨洁,叶冰璐,杜唯佳,刘志强.催产素调控焦虑情绪及其行为的神经生物学机制研究进展[J].同济大学学报(医学版),2022,43(6):889-894. |
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| 作者姓名： | 李雨洁 叶冰璐 杜唯佳 刘志强 |
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| 作者单位： | 同济大学医学院,上海200092; 同济大学附属第一妇婴保健院麻醉科,上海201204 |
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| 基金项目： | 上海申康医院发展中心诊疗技术示范推广应用项目(SHDC22020205)；上海市科委医学引导类中西医项目(19401930500) |
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| 摘 要： | 催产素作为中枢神经调质参与社会行为及情绪障碍的发生及调控逐渐被重视。本文就催产素与焦虑症的神经生物学研究近期进展做一综述，阐明催产素介导焦虑情绪及调控焦虑样行为的作用受体、脑区、神经元类型及相关环路，同时就催产素及其受体系统与焦虑情绪相关的表观遗传学调控及临床应用进行简介，旨在为拓展催产素在焦虑症相关精神疾病中的应用提供借鉴与依据。
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| 关 键 词： | 催产素 下丘脑室旁核 焦虑 |
| 收稿时间： | 2022/1/24 0:00:00 |
Recent advances in neurobiological mechanism of oxytocin regulating anxiety emotion and behavior |
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| LI Yujie,YE Binglu,DU Weiji,LIU Zhiqiang.Recent advances in neurobiological mechanism of oxytocin regulating anxiety emotion and behavior[J].Journal of Tongji University(Medical Science),2022,43(6):889-894. |
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| Authors: | LI Yujie YE Binglu DU Weiji LIU Zhiqiang |
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| Institution: | School of Medicine, Tongji University, Shanghai 200092, China; Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China |
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| Abstract: | The role of oxytocin as a neuromodulator in regulating behavior and emotion has been recognized. This article reviews the recent research advances in the mechanisms of oxytocin regulating anxiety-like behavior, focusing on the related receptors, neurons and downstream brain regions, as well as the neurotransmitters and neuroendocrine system. At the same time, the epigenetic regulation and related receptors of oxytocin are briefly introduced to provide reference for its clinical application in the treatment of anxiety disorders. |
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| Keywords: | oxytocin paraventricular nucleus of hypothalamus anxiety |
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