Brain imaging findings in very preterm infants throughout the neonatal period: Part II. Relation with perinatal clinical data |
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| Authors: | Lara M. Leijser Sylke J. Steggerda Francisca T. de Bruïne Jeroen van der Grond Frans J. Walther Gerda van Wezel-Meijler |
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| Affiliation: | 1. Department of Paediatrics, Division of Neonatology, J6-S, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands;2. Department of Radiology, C3-Q, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands;1. Department of Pediatrics, University of Rochester, Rochester, NY;2. Department of Neurology, University of Rochester, Rochester, NY;3. Department of Pediatrics, Maimonides Medical Center, Brooklyn, NY;4. Department of Pediatrics, University of North Carolina, Chapel Hill, NC;5. Department of Pediatrics, Emory University, Atlanta, GA;1. Molecular and Cellular Pharmacology Training Program, University of Wisconsin-Madison, 1202 W Johnson St., Madison, WI 53706, United States;2. Department of Psychology, University of Wisconsin-Madison, 1202 W Johnson St., Madison, WI 53706, United States;3. Neuroscience Training Program, University of Wisconsin-Madison, 1202 W Johnson St., Madison, WI 53706, United States;1. 3rd Department of Obstetrics and Gynecology, Attikon University Hospital, 12462 Athens, Greece;2. Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany;3. 4th Department of Internal Medicine, Attikon University Hospital, 12462 Athens, Greece;1. Division of Neonatology, Department of Pediatrics, Nationwide Children''s Hospital and The Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio;2. Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center, Houston, Texas;3. Center for Perinatal Research, The Research Institute at Nationwide Children''s Hospital and The Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio |
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| Abstract: | This study describes the relation between frequent and clinically relevant brain imaging findings in very preterm infants (GA < 32 weeks), assessed with sequential cranial ultrasonography throughout the neonatal period and MRI around term age, and several potential perinatal risk factors.For ultrasound findings during admission the following independent risk factors were identified: male gender for periventricular echodensities and intraventricular haemorrhage, postnatal corticosteroid treatment for cystic white matter lesions, and lower gestational age for post-haemorrhagic ventricular dilatation. For MRI findings around term age, including punctate white matter lesions, ventricular dilatation, decreased cortical complexity, and diffuse and excessive high signal intensity, no independent risk factors were found.In very preterm infants, the risk factors for frequently found changes on cranial ultrasound have largely remained unchanged over the last decades, while no risk factors could be identified for subtle and diffuse white matter injury as seen on MRI around term age. |
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