柴胡龙骨牡蛎汤治疗肝郁气滞型失眠临床疗效观察

目的:观察柴胡龙骨牡蛎汤对肝郁气滞型型失眠患者的临床疗效。方法:选择2016年1月—2020年1月在安徽省阜阳市人民医院治疗的失眠患者160例,中医辨证为肝郁气滞型者。按照随机数字表法,随机分为对照组和治疗组各80例,观察治疗前后两组患者中医症候积分;治疗前后两组匹兹堡睡眠质量指数(PSQI)、睡眠效率值(IUSEV)、炎症因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、5-羟色胺(5-HT)、多巴胺(DA)、γ-氨基丁酸(GABA)水平的变化。结果:治疗组的中医症状积分、匹兹堡睡眠质量指数较对照组明显降低,差异有统计学意义(P<0.05);治疗组的睡眠效率值指标较对照组明显增高,差异有统计学意义(P<0.05);治疗组的IL-6和TNF-α指标较对照组均明显下降,差异有统计学意义(P<0.05);与本组治疗前比较,两组治疗后的5-HT和GABA水平均升高,DA水平明显降低,差异有统计学意义(P<0.05)。结论:对于肝郁气滞型失眠患者联合运用柴胡龙骨牡蛎汤治疗,能明显降低中医症状积分、降低PSQI积分、降低炎症因子、提高睡眠效率值,改善患者睡眠质量,且无毒副作用。

Clinical Effect of Chaihu Longgu Muli Decoction in Treating Insomnia of Liver-Qi Stagnation

Objective:To observe the clinical effect of Chaihu Longgu Muli Decoction in treating insomnia of Liver-qi stagnation pattern.Methods:160 patients with insomnia were randomly divided into the control group(n=80)and the treatment group(n=80).The control group was treated with Alprazolam;on which basis,the treatment group was also treated with Chailu Longgu Muli Decoction.The scores of TCM symptoms,PSQI and IUSEV,as well as the levels of IL-6,TNF-α,5-HT,DA and GABA were observed before and after the treatment in the two groups.Results:The scores of TCM symptoms and PSQI were significantly lower in the treatment group than those in the control group after the treatment(P<0.05).The scores of IUSEV were significantly increased in the treatment group than those in the control group after the treatment(P<0.05).The levels of IL-6 and TNF-αwere significantly decreased in the treatment group than those in the control group after the treatment(P<0.05).The levels of 5-HT and GABA were significantly increased,and the level of DA was obviously decreased after the treatment compared to those before the treatment in the two groups(P<0.05).Conclusion:Chaihu Longgu Muli Decoction combined with Alprazolam can significantly reduce the scores of TCM symptoms and PSQI,decrease the levels of inflammatory factors and increase the scores of IUSEV and improve sleep quality in the treatment of insomnia of Liver-qi stagnation.