| 中国动脉粥样硬化近三年基础研究进展 |
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| 引用本文： | 支晨曦,谢忠成,李靓,彭田红,谢巍.中国动脉粥样硬化近三年基础研究进展[J].中国动脉硬化杂志,2022,30(9):744-752. |
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| 作者姓名： | 支晨曦 谢忠成 李靓 彭田红 谢巍 |
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| 作者单位： | 南华大学衡阳医学院应用解剖与生殖医学研究所,湖南省衡阳市 421001 |
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| 基金项目： | 国家自然科学基金资助项目(81800386)；湖南省自然科学基金资助项目(2021JJ30020)；湖南省卫生健康委科研课题立项资助项目(202101021784) |
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| 摘 要： | 动脉粥样硬化(As)是一种与心血管疾病密切相关的病理过程，严重威胁人类健康。近三年来，中国学者主要致力于As模型的构建，聚焦铁死亡、焦亡、自噬、肠道微生物菌群、外泌体、氧化应激、低剪切应力、非编码RNA与As的关系，并进行了大量深入的研究工作。广泛而深入的基础研究为As防治策略的选择和药物的研发提供新的思路，以期实现临床转化。文章就近三年来中国学者围绕上述领域对As开展的基础研究作一综述。
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| 关 键 词： | 动脉粥样硬化 程序性死亡 肠道微生物菌群 低剪切应力 非编码RNA |
| 收稿时间： | 2022/1/21 0:00:00 |
| 修稿时间： | 2022/4/20 0:00:00 |
The progress of the national preclinical research of atherosclerosis in the recent three years |
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| ZHI Chenxi,XIE Zhongcheng,LI Liang,PENG Tianhong,XIE Wei.The progress of the national preclinical research of atherosclerosis in the recent three years[J].Chinese Journal of Arteriosclerosis,2022,30(9):744-752. |
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| Authors: | ZHI Chenxi XIE Zhongcheng LI Liang PENG Tianhong XIE Wei |
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| Institution: | Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China |
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| Abstract: | Atherosclerosis (As) is a pathological process which is tightly related to cardiovascular diseases. Because of its high risks to human health, Chinese scholars have carried out a large number of researches in recent 3 years, which focus on the model and the pathogenesis and risk factors of As, such as ferroptosis, pyroptosis, autophagy, gut microflora, exosomes, oxidative stress, low shear stress, non-coding RNA. Intensive and in-depth preclinical researches provide novel ideas for the selection of prevention and treatment strategies and drug research of As, in order to achieve clinical transformation. This paper reviews the preclinical researches on As conducted by Chinese scholars in recent 3 years. |
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| Keywords: | atherosclerosis programmed death gut microbiota low shear stress non-coding RNA |
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