RhoA/ROCK信号通路与动脉粥样硬化关系的研究进展

动脉粥样硬化是一种常见的全身性血管疾病,同时也是多种急性心血管疾病的病理基础。而急性心血管疾病的死亡率高,严重危害人们的生命健康。近年来,越来越多的研究表明RhoA/ROCK信号通路与动脉粥样硬化的形成有密切联系。抑制RhoA/ROCK信号通路可以通过稳定血管内皮功能、抑制血管平滑肌细胞增殖和迁移、抑制血管钙化、调控炎症细胞聚集以及抑制血小板增殖变形来延缓或抑制动脉粥样硬化的形成。

Research progress on the relationship between RhoA/ROCK signaling pathway and atherosclerosis

Atherosclerosis is a common systemic vascular disease, and it is also the pathological basis of a variety of acute cardiovascular diseases. Acute cardiovascular disease has a high mortality rate, which seriously endangers people''s life and health. In recent years, more and more studies have shown that the RhoA/ROCK signaling pathway is closely related to atherosclerosis. Inhibition of RhoA/ROCK signaling pathway can delay or inhibit the formation and pathological changes of atherosclerosis by stabilizing vascular endothelial function, inhibiting the proliferation and migration of vascular smooth muscle cells, inhibiting vascular calcification, regulating inflammatory cell aggregation, and inhibiting platelet proliferation and deformation.