遗传因素在动脉粥样硬化发生与防治中的作用

动脉粥样硬化是在遗传与环境等多种因素作用下经过长期演进发展而形成的一类复杂疾病。在整个疾病的发展演进过程中,遗传因素决定表型出现的临界点,而环境因素决定个体在这个临界点内的危险度。在一些罕见病例,动脉粥样硬化的发病可以符合孟德尔遗传规律,如家族性高胆固醇血症患者的动脉粥样硬化。然而,即使这样一个病因明确的单基因病,其外显率仍然存在很大的差异。对这一现象可解释为相同的基因突变对不同个体携带者影响的程?...

Study of Nitric Oxide as Molecular Marker of Prestroke State in Hypertensive Rats

Aim To investigate changes of serum nitric oxide(NO) in stroke-prone renovascular hypertensive rats(RHRSP) before artificicial cold.To explore the possibility of nitric oxide used as the prediction index of stroke. Methods Two-kidney,two-clip methods were used to copy the model of renovascular hypertension in rats,Serum NO levels were measured by nitrate reductase before and after artificicial cold. Results Serum NO levels in cerebral infarction group and cerebral hemorrhage group were significantly lower than that in the non-stroke group before artificicial cold;serum NO levels in cerebral infarction group and cerebral hemorrhage group after artificicial cold were significantly lower than that before artificicial cold. Conclusion Serum NO could be used as the prediction index of stroke.