| 藤梨根化学成分及其体外抗肿瘤转移活性 |
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| 引用本文： | 甘椿椿,金湛,魏晓鹏,靳美娜. 藤梨根化学成分及其体外抗肿瘤转移活性[J]. 中成药, 2021, 0(2): 403-407 |
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| 作者姓名： | 甘椿椿 金湛 魏晓鹏 靳美娜 |
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| 作者单位： | 衢州职业技术学院;天津医科大学 |
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| 基金项目： | 天津市自然科学基金(18JCQNJC13800);衢州市科技攻关项目(2018K23)。 |
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| 摘 要： | 目的 研究藤梨根Actinidia chinensis Planch的化学成分及其体外抗肿瘤转移活性.方法 藤梨根95％乙醇提取物采用硅胶、Toyopearl HW-40、制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构.通过划痕实验和Transwell实验来评价其体外抗肿瘤转移活性.结果 从中分离...
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| 关 键 词： | 藤梨根 化学成分 分离鉴定 抗肿瘤转移 |
Chemical constituents from Actinidia chinensis and their antitumor metastatic activity in vitro |
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| GAN Chun-chun,JIN Zhan,WEI Xiao-peng,JIN Mei-na. Chemical constituents from Actinidia chinensis and their antitumor metastatic activity in vitro[J]. Chinese Traditional Patent Medicine, 2021, 0(2): 403-407 |
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| Authors: | GAN Chun-chun JIN Zhan WEI Xiao-peng JIN Mei-na |
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| Affiliation: | (Quzhou College of Technology,Quzhou 324000,China;Tianjin Medical University,Tianjin 300070,China) |
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| Abstract: | AIM To study the chemical constituents from Actinidia chinensis Planch and their antitumor metastatic activity in vitro.METHODS The 95%ethanol extract from A.chinensis was isolated and purified by silica,Toyopearl HW?40 and p?HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Wound healing and Transwell assays were used to assay their antitumor metastatic activity in vitro.RESULTS Eight compounds were isolated and identified asβ?sitosterol(1),3?oxo?urs?12?en?28?oic acid(2),ursolic acid(3),2α,3α,24?trihydroxyurs?12?en?28?oic acid(4),2α,3α,23?trihydroxyurs?12?en?28?oic acid(5),2α,3β?dihydroxyolean?12?en?28?oic acid(6),2α,3β,23,24?tetrahydroxyurs?12?en?28?oic(7),daucosterol(8).Compound 7 could obviously inhibit tumor cell metastasis in a certain dose?dependent manner.CONCLUSION Compound 2,7 are isolated from this plant for the first time,and compound 7 exhibites stronger antitumor metastatic activity in vitro. |
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| Keywords: | Actinidia chinensis Planch chemical constituents isolation and identification antitumor metastatic activity |
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