巨噬细胞极化在心肌纤维化中的作用及Notch信号通路相关研究

巨噬细胞是一类免疫功能多样且具有高度异质性的细胞群体,在不同微环境的刺激下,可极化为两个亚群:M1型和M2型,且在心肌纤维化发展不同阶段其极化表型及功能存在显著差异。即在心肌纤维化早期,M1型比例升高以促进炎症进展；在心肌纤维化后期,M2型比例升高以缓解心肌纤维化。Notch信号通路可调控巨噬细胞极化,与心肌纤维化的发展有关,尤其是在心肌梗死、心力衰竭等心血管疾病中。故阻断Notch信号通路有利于调控巨噬细胞极化,进而有助于抑制或逆转心肌纤维化进程。

The role of macrophage polarization in myocardial fibrosis and related research on Notch signaling pathway

Macrophages are a group of cells with diverse immune functions and high heterogeneity. Under the stimulation of different microenvironments, macrophages can be polarized into two subgroups:M1 and M2. There are significant differences in polarization phenotypes and function at different stages of myocardial fibrosis. That is, in the early stage of myocardial fibrosis, the proportion of M1 type increased to promote the progression of inflammation; in the later stage of myocardial fibrosis, the proportion of M2 type increased to alleviate myocardial fibrosis. The Notch signaling pathway can regulate macrophage polarization, which is related to the development of myocardial fibrosis, especially in cardiovascular diseases such as myocardial infarction and heart failure. Therefore, blocking the Notch signaling pathway is beneficial to regulating macrophage polarization, which is helpful to inhibit or reverse the process of myocardial fibrosis.