氢分子增强高密度脂蛋白介导的胆固醇排出功能:从动物实验到临床试验

高密度脂蛋白(HDL)具有介导胆固醇逆向转运、抗氧化等作用,从而抑制动脉粥样硬化。在代谢综合征、糖尿病、吸烟等情况下,HDL发生氧化修饰,HDL相关酶活性降低,导致其功能减弱。维生素E等抗氧化剂能减少HDL氧化修饰,增强HDL相关酶如对氧磷酶1等活性,但其长期使用的安全性有待验证。氢分子作为一种新型抗氧化剂,在多种氧化炎症性疾病中均发挥良好的作用。本课题组一直致力于氢分子与动脉粥样硬化性心血管疾病的研究,发现氢分子能提高代谢综合征和高胆固醇血症动物和人的血浆高密度脂蛋白胆固醇水平,增强HDL相关酶活性及其介导的胆固醇排出功能。本文就氢分子对HDL生物学效应的动物实验和临床试验进行综述。

Hydrogen molecule enhances high density lipoprotein-mediated cholesterol efflux:from animal experiments to clinical trials

Aim High density lipoprotein (HDL) has the functions of mediating reverse cholesterol transport and anti-oxidation, thereby inhibiting atherosclerosis. In the case of metabolic syndrome, diabetes, smoking, etc., HDL undergoes oxidative modification, and the activity of HDL-related enzymes decreases, resulting in weakened functions. Antioxidants such as vitamin E can reduce the oxidative modification of HDL and enhance the activity of HDL-related enzymes such as paraoxonase 1, but their long-term safety remains to be verified. Hydrogen molecule, as a novel antioxidant, plays a good role in a variety of oxidative inflammatory diseases. Our research group has been devoted to the research of hydrogen molecule and atherosclerotic cardiovascular disease, and found that hydrogen molecule can increase the plasma high density lipoprotein cholesterol level in animals and humans with metabolic syndrome and hypercholesterolemia, and enhance the activity of HDL-related enzymes and its mediated cholesterol efflux function. This article reviews the animal experiments and clinical trials of the biological effects of hydrogen molecule on HDL.