伴有钙化“混叠效应”的侵袭性乳头汗管瘤样腺瘤1例影像学特征

41岁女性患者因“右乳头增大6年”就诊。查体发现右侧乳头增大至约2 cm，质硬无压痛。钼靶 X线摄影示右乳头乳晕区细小钙化到环形钙化的多重混叠，超声提示右乳头多个钙化堆叠伴后方声影。行乳头乳晕复合体的扩大切除术并确定切缘阴性，术后病理诊断为侵袭性汗管瘤样腺瘤，部分区域伴有骨化。随访4年，患者至今未见复发。此良性肿瘤的X线、超声表现与既往文献报道的影像学特征明显不同。应提高对此病临床影像学表现多样性的认识。

Multiple Calcification of the Nipple Areola Complex: a Case Report of Infiltrating Syringomatous Adenoma of the Nipple

A 41 years old female patient experienced enlarged right nipple more than 6 years ago. Physical examination showed enlarged and hardened right nipple (about 2 cm) but no tenderness. Mammographic results showed the mixed calcification pattern, which was presenting multiple sizes of circular and granular calcification of the nipple areola complex. Ultrasound revealed large calcification in the nipple areola area with posterior acoustic shadow. This patient underwent extensive excision of the nipple areola complex. The surgical margin was confirmed to be negative. Postoperative pathology confirmed an infiltrating syringomatous adenoma with ossification in some areas. Tumor cell infiltration was not found at the surgical margin. After 4 years of follow-up, no recurrence was found. The mammography and ultrasound findings of this benign tumor were significantly different from those reported in previous literatures. We should improve the understanding of the variousness of clinical imaging manifestations of this disease.