脂噬在动脉粥样硬化中的作用及中医药干预研究进展

动脉粥样硬化(As)是一种多因素共同作用的慢性炎症性血管病变。脂质蓄积是As发生的关键病理因素之一，其通过触发血管内炎症细胞浸润、内皮细胞损伤、泡沫细胞形成、血管平滑肌细胞增殖及迁移等多个病理环节，最终导致As斑块形成。脂噬作为一种选择性的自噬进程，通过溶酶体介导选择性降解细胞内储存中性脂质的细胞器脂滴，减少脂质沉积，从而维持细胞稳态，成为As研究的新靶点。本文对细胞脂噬功能在As中的作用的研究进展及相关中医药治疗进行讨论，旨在从脂噬角度为中医药防治As提供可行性思路。

Research progress on the role of lipophagy in atherosclerosis and traditional Chinese medicine intervention

Atherosclerosis (As) is a chronic inflammatory disease of complex evolutionary caused by multiple factors. Lipid accumulation is one of the key pathological factors of As, which leads to the formation of As plaques by stimulating inflammatory cell infiltration, endothelial cell injury, foam cell formation and VSMC migration and proliferation. Lipophagy as a selective process of autophagy, it can selectively degradate intracellular lipid droplets via lysosome-mediated and reduce lipid deposition and maintain intracellular lipid homeostasis, which can be used as a new target for As research.This artical discusses the research progress on the role of lipophagy in As and related traditional Chinese medicine treatment to provide feasible ideas for traditional Chinese medicine preventing and treating As from the view of lipophagy.