| 纳米载药在心肌梗死及其并发症防治中的应用 |
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| 引用本文： | 朴明慧,曲文博,刘冰,田进伟.纳米载药在心肌梗死及其并发症防治中的应用[J].中国动脉硬化杂志,2021,29(11):989-994. |
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| 作者姓名： | 朴明慧 曲文博 刘冰 田进伟 |
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| 作者单位： | 哈尔滨医科大学附属第二医院心血管内科,黑龙江省哈尔滨市 150001;哈尔滨医科大学药学院, 黑龙江省哈尔滨市 150081;黑龙江省医学科学院北方转化医学研究合作中心,黑龙江省哈尔滨市 150081;哈尔滨医科大学附属第二医院心血管内科,黑龙江省哈尔滨市 150001;哈尔滨市心肌缺血教育部重点实验室,黑龙江省哈尔滨市 150001 |
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| 基金项目： | 国家重点研发计划(2016YFC1301304)；霍英东青年教师基金(171032) |
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| 摘 要： | 心肌梗死及其并发的恶性心律失常和病理性心室重塑严重危害人类健康。药物治疗是目前稳定斑块及减少心肌缺血再灌注损伤的主要手段。近来研究显示,纳米载药在靶向治疗、增强药物安全性以及有效性等方面具有巨大潜力。本文综述了纳米载药的发展现状,并对其在治疗心肌梗死及相关并发症中的应用前景进行展望。
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| 关 键 词： | 动脉粥样硬化 心肌梗死 纳米载药 |
| 收稿时间： | 2020/5/19 0:00:00 |
| 修稿时间： | 2020/6/20 0:00:00 |
Application of nano-drug delivery for treatment of myocardial infarction and its complications |
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| PIAO Minghui,QU Wenbo,LIU Bing,TIAN Jinwei.Application of nano-drug delivery for treatment of myocardial infarction and its complications[J].Chinese Journal of Arteriosclerosis,2021,29(11):989-994. |
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| Authors: | PIAO Minghui QU Wenbo LIU Bing TIAN Jinwei |
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| Institution: | Deparment of Cardiovascular Medicine, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China;College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, China;Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, Heilongjiang 150081, China; Deparment of Cardiovascular Medicine, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China;The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang 150001, China |
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| Abstract: | Myocardial infarction (MI) and its concomitant malignant arrhythmia, pathological ventricular remodeling and other complications are seriously harmful to human health. At present, drug therapy is the main strategy to stabilize plaque and reduce myocardial ischemia-reperfusion injury. Recent studies have shown that nano-drug delivery has great potential to benefit targeted therapy and enhance the safety and efficacy of drug treatment. This paper summarizes the present development of nano-drug delivery, and reviews the prospects of the treatment of myocardial infarction and its complications. |
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| Keywords: | atherosclerosis myocardial infarction nano-drug delivery |
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