巨噬细胞及其亚型在动脉粥样硬化中的研究进展

巨噬细胞和动脉粥样硬化的发生、发展密切相关，分布在粥样斑块中的巨噬细胞又可分为M1、M2等不同亚型。不同亚型的巨噬细胞具有不同、甚至是相反的生理功能，其对动脉粥样硬化的病程也有不同的影响。因此利用药物以调控动脉粥样斑块内巨噬细胞不同亚型的分化为靶点干预病程进展可能是一种潜在的有效治疗措施。

Macrophages Subtypes and Atherosclerosis

Macrophages are closely related to the initiation and progression of atherosclerosis, and the macrophages which are distributed in the atherosclerotic plaque can be subdivided into different subsets of M1 macrophages and M2 macrophages and so on. The different subtypes perform different function and the different subpopulations may influence the disease process in different way, so to treat atherosclerosis by the drug to control differentiation of macrophages subsets might be a new therapeutic target.