| 大鼠深部浸润型子宫内膜异位症模型的建立和比较 |
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| 引用本文： | 张薇,邹移海,张钟广,胡海勋,苏小华,黄海定,黎福荣,林以理,郭学军.大鼠深部浸润型子宫内膜异位症模型的建立和比较[J].广东寄生虫学会年报,2010(9):1042-1044,1047,F0003. |
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| 作者姓名： | 张薇 邹移海 张钟广 胡海勋 苏小华 黄海定 黎福荣 林以理 郭学军 |
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| 作者单位： | [1]中山大学实验动物中心,广州510080 [2]广州中医药大学,广州510405 [3]中山大学药学院,广州510006 [4]广东医学院实验动物中心,湛江524005 |
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| 基金项目： | 广东省科技基础条件建设项目（No.2007A060305005） |
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| 摘 要： | 目的建立SD、Wstar大鼠深部浸润型子宫内膜异位症模型,并进行比较研究。方法采用外科诱导法对10只SD、30只Wistar雌性大鼠行自体子宫组织子宫直肠凹移植手术。结果 SD大鼠成模率80.0%,Wstar大鼠成模率76.7%;SD大鼠手术死亡率（10.0%）比Wstar大鼠死亡率（23.3%）低（P〈0.05）;Wistar大鼠在成活的动物中可达到100%的成模,且形成的移植物体积较SD大鼠大（P〈0.05）。结论应用SD和Wistar大鼠采用子宫直肠凹种植子宫内膜均可成功地建立深部浸润内异症模型。
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| 关 键 词： | 大鼠 子宫内膜异位症 模型 深部浸润 |
Establishment and Comparison of Rat Deep Infiltrating Endometriosis Model |
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| ZHANG Wei,ZOU Yi-hai,ZHANG Zhong-guang,HU Hai-xun,SHU Xiao-hua,HUANG Hai-ding,LI Fu-rong,LIN Yi-li,GUO Xue-jun.Establishment and Comparison of Rat Deep Infiltrating Endometriosis Model[J].Journal of Tropical Medicine,2010(9):1042-1044,1047,F0003. |
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| Authors: | ZHANG Wei ZOU Yi-hai ZHANG Zhong-guang HU Hai-xun SHU Xiao-hua HUANG Hai-ding LI Fu-rong LIN Yi-li GUO Xue-jun |
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| Institution: | 1.Laboratory Animal Center of Sun Yat-sen University, Guangzhou 510080; 2.Laboratory Animal Center of Guangzhou University of Chinese Medicine, Guangzhou 510405; 3.School of Pharmaceutical Sciences of Sun Yat-sen University, Guangzhou 510006; 4.Laboratory Animal Center of Guangdong Medical College, Zhanjiang 524005, China) |
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| Abstract: | Objective To establish the deep infiltrating endometriosis model using SD and Wistar female rat and to conduct the comparative study.Methods 10 SD and 30 Wistar rats were transplanted with autologous concave rectum uterus using surgery-induced method.Results The successful rate in the SD rats was 80.0% and the successful rate for Wistar rats was 76.7%.The mortality for SD was 10.0% and for Wistar was 23.3% （P0.05）.The survival rate of Wistar rat can be 100%, and the volume of graft formation was bigger than the SD rat （P0.05）.Conclusion The establishment of deep infiltrating endometriosis model in Wistar and SD rat is feasible.It can be achieved by transplanting the uterine endometrial in uterus rectum concave. |
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| Keywords: | rats endometriosis model deep infiltration |
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