p53蛋白在宫颈鳞癌组织中的表达及意义

目的探讨p53蛋白在宫颈鳞癌组织中的表达及临床意义。方法应用免疫组化SP法分别对宫颈鳞癌切除标本和正常宫颈组织标本中的p53蛋白的表达状况进行检测。结果 p53蛋白在35例正常组织中不表达,在65例宫颈鳞癌组织中,p53蛋白阳性表达38例,阳性率为58.46%。癌组织中p53蛋白的表达率与正常组织比较差异有统计学意义（P〈0.05）。p53蛋白的阳性表达率与年龄及临床分期差异无统计学意义（P〉0.05）,即p53蛋白表达阳性与宫颈鳞癌患者年龄及临床分期无明显相关。p53蛋白的表达量与宫颈鳞癌的分化程度及局部淋巴结转移差异有统计学意义（P〈0.05）,即p53蛋白的表达量与病理分化程度及局部淋巴结转移有关。结论 p53蛋白的表达与宫颈鳞癌的发生发展有关,可作为宫颈鳞癌的早期诊断、治疗及预后评估的一项参考指标。

Abnormal Expression and Significance of the Tumor Suppressor Gene p53 in Cervical Squamous Cell Carcinoma

Objective To study the expression and clinical significance of the tumor suppressor gene p53 in cervical squamous cell carcinoma.Method The expression of p53 protein in the cancer specimens and normal cervical tissue was examined by immunohistochemistical method..Results Expression of p53 was not detected in normal cervical tissue.The positive rate of expression was 58.46% in 65 samples of cervical squamous cell carcinoma.The expression rate of the p53 in cervical squamous cell carcinoma was significantly different from the normal tissue（P 0.05）.The positive expression rate of the p53 was not correlated with the clinical stage and age（P0.05） of the patients.The expression of the p53 was significantly correlated with the degree of differentiation of the squamous cell and the local lymph node metastasis（P0.05）.Conclusions The generation and development of the cervical cancer is correlated with the expression of p53.The expression of p53 can be considered as a reference index for the early diagnosis of cervical cancer,treatment and prognosis appraisal.