2008年广州市花都区乙型肝炎感染情况调查

目的了解广州市花都区人群乙型肝炎的感染率、分布特征和发展趋势，为该区评价和制定乙肝防制措施提供科学依据。方法采用分层随机抽样的方法对样本人群进行血清流行病学调查，并分析结果。结果共调查1～59岁人群419人，HBsAg总携带率为9．1％，将调查人群分为1，岁、7。岁、17．59岁3个年龄组，结果3组的HBsAg携带率分别为2．2％、1．9％、15．0％，HBsAg阳性率随着年龄增高而增高，不同年龄组HBsAg携带率差异有统计学意义（P〈0．05）；男女性的阳性携带率分别是8．9％和9．1％，差异无统计学意义（P〉0．05）；抗-HBs总阳性率为66-3％，各年龄组的阳性率分别为82．0％、60．2％、63．0％，不同年龄组抗-HBs阳性差异有统计学意义（P〈0．01）；不同地区HBsAg携带率、抗-HBs水平差异无统计学意义（P〉0．05）。HBVM全阴率男女性分别为46．9％和51．5％，差异无统计学意义（P〉0．05）；HBVM全阴率在各年龄组分布差异有统计学意义（P〈0．01），随着年龄的增大而下降。结论花都区自1992年实行新生儿乙肝疫苗大规模接种以来，乙肝发病得到了有效控制。

Hepatitis B Infection in Huadu District of Guangzhou City in 2008

Objective To provide the scientific basis for appraisal and work out measures against hepatitis B through the investigation of the infection rate, distribution characteristic and trends of development of hepatitis B of Huadu district. Method Individuals were obainted by the lamination random sampling method, and carried on the seroepidemiological investigation. Results A total of 419 from 1 to 59-year-old was investigated.The total carrying rate of HBsAg was 9.1%.The study subjects were divided into three groups 1 -years,7-years,and 17-59 years. HBsAg carrying rate of the three age groups were 2.2%, 1.9% and 15.0% ,respectively.The HBsAg carrying rate increases with the age. The HBsAg carrying rate in different age groups was significantly different（P〈0.05）. The male carrying rate was 8.9%, while the female was 9.1%, without statistically significant difference （P〉0.05）. The total positive rate of HBsAb was 66.3%.The positive rates of the three age groups were 82.0% ,60.2% and 63.0% , respectively. The positive rates of different age groups were significantly different（P〈0.01 ）. The HBsAg carrying rates in different regions had no significant differences （P〉0.05）. The overall level of HBsAb was no significant differences （P〉0,05）. The negative rates of the HBVM of the male and female were 46.9% and 51.5%, respectively, with no significant differences（P〉0.05）. The negative rates of the HBVM of the three age groups were significantly different（P 〈0.01） ,which declined with the increase in age. Conclusion Hepatitis B had been effectively controlled in the whole region, due to the wide application of hepatitis B vaccine to new-born infants in Huadu district since 1992.