| 氟哌啶醇口腔崩解片的制备及质量评价 |
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| 引用本文： | 胡盛松,王清.氟哌啶醇口腔崩解片的制备及质量评价[J].中国实用医药,2010,5(10):13-15. |
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| 作者姓名： | 胡盛松 王清 |
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| 作者单位： | 1. 湖南中医药大学第一附属医院药剂科,410007
2. 长沙航空职业技术学院化工与环保系 |
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| 摘 要： | 目的制备氟哌啶醇口腔崩解片,并评价其质量。方法直接粉末压片法制备口腔崩解片。以片剂崩解时限、口感为指标,采用正交实验设计优化处方,并对其溶出度进行检测。结果所得片剂完整光洁,口感良好,与市售普通片比较,口腔崩解片具有明显速释效果。结论氟哌啶醇口腔崩解片处方设计合理,制备工艺可行,产品质量可控。
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| 关 键 词： | 氟哌啶醇 口腔崩解片 处方工艺 质量评价 |
Preparation and quality control of Haloperidol orally disintegrating tablet |
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| HU Sheng-song,WANG Qing.Preparation and quality control of Haloperidol orally disintegrating tablet[J].China Practical Medical,2010,5(10):13-15. |
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| Authors: | HU Sheng-song WANG Qing |
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| Institution: | HU Sheng-song,WANG Qing.Pharmacy of The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Hunan,Changsha 410007,China |
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| Abstract: | Objective To prepare orally disintegrating tablets containing Haloperidol and investigate its quality.Methods The tablets were prepared using the direct compression method.The formulation was optimized with disintegration time and taste as reference parameters by an orthogonal design,and their dissolution were examined.Results The orally disintegrating tablets were integrity and smooth with desirable taste and feel in the mouth.The orally disintegrating tablets had better fast release effect than marketed t... |
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| Keywords: | Haloperidol Orally disintegrating tablet Formulation Quality control |
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