| 反相高效液相色谱法测定氟康唑搽剂中氟康唑含量 |
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| 引用本文： | 霍玉,马克勤. 反相高效液相色谱法测定氟康唑搽剂中氟康唑含量[J]. 中国药业, 2009, 18(8): 33-34 |
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| 作者姓名： | 霍玉 马克勤 |
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| 作者单位： | 1. 山东省潍坊市药品检验所,山东,潍坊,261041
2. 山东省潍坊市人民医院,山东,潍坊,261041 |
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| 摘 要： | 目的建立测定氟康唑搽剂含量的反相高效液相色谱（RP—HPLC）法。方法色谱柱为Diamonsil C18柱（250mm×4．6mm，5μm），流动相为磷酸盐缓冲液（pH=7．0）-甲醇（55：45），检测波长为261nm。结果氟康唑进样量的线性范围为1．2～6．0μg，平均回收率为99．73％，RSD=0．30％（n=6）。结论该法简便、准确、重现性好，可用于氟康唑搽剂的含量测定。
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| 关 键 词： | 氟康唑搽剂 氟康唑 含量测定 反相高效液相色谱法 |
Determination of Fluconazole in Fluconazole Liniment by RP-HPLC |
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| Huo Yu,Ma Keqin. Determination of Fluconazole in Fluconazole Liniment by RP-HPLC[J]. China Pharmaceuticals, 2009, 18(8): 33-34 |
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| Authors: | Huo Yu Ma Keqin |
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| Affiliation: | 1. Weifang Institute for Drug Control, Weifang, Shandong, China 261041; 2. Weifang People＇s Hospital, Weifang, Shandong, China 261041 ) |
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| Abstract: | Objective To establish a RP-HPLC method for the assay of fluconazole in Fluconazole Limiment. Methods RP-HPLC was performed on Diamonsil C18 column（250mm×4.6 mm, 5μm） with phosphate buffer solution pH=7.0-methanol（55：45） as the mobile phase. The detection wavelength was 261 nm. Results The linear range of fluconazole on calibration curve was 1.2-6. 0 μg. The average recovery rate was 99.73%, RSD =0. 30% （n =6）. Conclusion The method is simple, accurate and reproducible. It can be used for the quality control of Fluconazole Liniment. |
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| Keywords: | Fluconazole Liniment fluconazole content determination RP - HPLC |
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