S100A14在子宫内膜癌中的表达及其意义 |
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引用本文: | 侯文萍,钱景锋,井超,王翔宇,贺欢,刘芝华,崔竹梅.S100A14在子宫内膜癌中的表达及其意义[J].现代妇产科进展,2014(9):677-680. |
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作者姓名: | 侯文萍 钱景锋 井超 王翔宇 贺欢 刘芝华 崔竹梅 |
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作者单位: | 1. 青岛大学附属医院妇产科,青岛,266101 2. 北京大学人民医院妇产科,北京,100191 3. 中国医学科学院肿瘤研究所,北京,100021 |
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摘 要: | 目的:探讨S100A14在子宫内膜样腺癌中的表达及其临床意义。方法:采用免疫组化法检测子宫内膜癌组织、不典型增生子宫内膜组织、单纯性增生子宫内膜组织及正常子宫内膜组织中S100A14的表达情况。结果:84例子宫内膜癌患者中,高、中分化与低分化癌组织中S100A14表达具有统计学差异(P=0.020,P=0.034);行淋巴结清扫的74例子宫内膜癌患者中,淋巴结阴性与淋巴结阳性癌组织中S100A14表达有统计学差异(P=0.044)。子宫内膜癌组织中S100A14的表达与正常内膜组织比较,差异有统计学意义(P=0.034),单纯性增生、不典型增生子宫内膜组织中S100A14的表达与正常内膜组织比较,无统计学差异。结论:S100A14的表达下调与子宫内膜样腺癌的恶性程度及肿瘤转移程度相关。
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关 键 词: | 子宫内膜癌 S100A14 免疫组化 |
Expression and significance of $100A14 protein in endometrial adenocarcinomas. |
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Institution: | Hou Wenping , Qian Jingfeng2, Jing Chao3, et al.( 1. Department of Obstetrics and Gynecology, The Af- filiated Hospital of Qingdao University, Qingdao 266101 ;2. Department of Obstetrics and Gynecology,Peking University People's Hospital,Beijing 100191 ;3. State Key Laboratory of Molecular Oncology , Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking U- nion Medical College,Beijing 100021) |
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Abstract: | Objective:To investigate the clinical significance of S100A14 in endometrial adenocarcinomas. Method:The expression of S100A14 was examined by immunohistochemistry analysis in tissue microarrays which contains four kinds of tissues:endometrial carcinoma, atypical endometrial tissues, hyperplasia endometrial tissues and normal endometrial tissues. Resuit:The expression of S100A14 in endometrial carcinoma tissues was significantly less than that in normal endometrial tissues (P = 0. 034). Among 85 endometrial carcinoma patients, S100A14 expression was significantly different between well differentiated and poorly differenti- ated patients(P=0. 020). The expression of S100A14 in moderately differentiated endometrial cancers was significantly higher than that in low differentiated endometrial cancers (P = 0. 034). There were 74 patients who went on extrafascial hysterectomy or extensive hysterectomy plus bilateral salpingo-oophorectomy and pelvic lymphadenectomy. S100A14 was significantly less in tissues with lymph node metastasis than those without lymph node metastasis (P = 0. 044). Conclusion:Decreased expression of S100A14 is correlated with higher metastatic potential and more poorly differentiated degree in human endometrial adenocarcinomas. |
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Keywords: | Endometrial adenocarcinomas S100A14 Immunohistochemistry |
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