S100A14在子宫内膜癌中的表达及其意义

目的:探讨S100A14在子宫内膜样腺癌中的表达及其临床意义。方法:采用免疫组化法检测子宫内膜癌组织、不典型增生子宫内膜组织、单纯性增生子宫内膜组织及正常子宫内膜组织中S100A14的表达情况。结果:84例子宫内膜癌患者中,高、中分化与低分化癌组织中S100A14表达具有统计学差异(P=0.020,P=0.034);行淋巴结清扫的74例子宫内膜癌患者中,淋巴结阴性与淋巴结阳性癌组织中S100A14表达有统计学差异(P=0.044)。子宫内膜癌组织中S100A14的表达与正常内膜组织比较,差异有统计学意义(P=0.034),单纯性增生、不典型增生子宫内膜组织中S100A14的表达与正常内膜组织比较,无统计学差异。结论:S100A14的表达下调与子宫内膜样腺癌的恶性程度及肿瘤转移程度相关。

Expression and significance of $100A14 protein in endometrial adenocarcinomas.

Objective：To investigate the clinical significance of S100A14 in endometrial adenocarcinomas. Method：The expression of S100A14 was examined by immunohistochemistry analysis in tissue microarrays which contains four kinds of tissues：endometrial carcinoma, atypical endometrial tissues, hyperplasia endometrial tissues and normal endometrial tissues. Resuit：The expression of S100A14 in endometrial carcinoma tissues was significantly less than that in normal endometrial tissues （P = 0. 034）. Among 85 endometrial carcinoma patients, S100A14 expression was significantly different between well differentiated and poorly differenti- ated patients（P=0. 020）. The expression of S100A14 in moderately differentiated endometrial cancers was significantly higher than that in low differentiated endometrial cancers （P = 0. 034）. There were 74 patients who went on extrafascial hysterectomy or extensive hysterectomy plus bilateral salpingo-oophorectomy and pelvic lymphadenectomy. S100A14 was significantly less in tissues with lymph node metastasis than those without lymph node metastasis （P = 0. 044）. Conclusion：Decreased expression of S100A14 is correlated with higher metastatic potential and more poorly differentiated degree in human endometrial adenocarcinomas.