气溶胶粒子在呼吸系统内沉降规律的数值模拟

目的：研究可吸入气溶胶粒子在人体气管、支气管内的沉积规律。方法：建立基于Weibel模型的G0～G3级气管、支气管模型,在呼吸强度为15、30和60 L/min时,设定不同的出口边界条件,模拟气溶胶粒子不同密度和不同粒子直径时的颗粒沉积情况。结果：不同的边界条件下,流场变化不大,对粒子的沉积影响不大。相对于粒子密度,粒子的直径和呼吸强度对沉积规律的影响更大。结论：该研究对于开发新的气溶胶吸入治疗药物和新的气溶胶吸入治疗装置具有一定的借鉴意义,为进一步研究气溶胶浓度和失能剂起效的血药浓度的对应关系提供了一定的依据。

Numerical simulation on deposition of aerosol particles in respirator trace

Objective To study the deposition of inhalable aerosol particles in the trachea and bronchia. Methods A tracheal bronchus model of generation G0 to G3 based on Weibel＇s model was built. The aerosol particles deposition was simulated under breathing intensity of 15, 30 and 60 L/min, with different outlet boundary conditions, densities and diameters. Results Flow field differed little as the boundary changed, while the breath densities and particle diameters had more influences on the deposition. Conclusion The study can help to develop aerosol inhalable medicine and apparatus,and to determine the correlation between the aerosol concentration and blood drug level when the incapacitating agent comes into effect.