Bioactive triterpenoids from Callistemon lanceolatus |
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| Authors: | Wonsik Jeong Seong Su Hong Nahyun Kim Young Taek Yang Yu Su Shin Chul Lee Bang Yeon Hwang Dongho Lee |
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| Affiliation: | (1) School of Life Sciences and Biotechnology, Korea University, Seoul, 136-713, Korea;(2) Jeju Special Self-Governing Province Agricultural Research and Extension Services, Jeju, 690-909, Korea;(3) Depatment of Herbal Crop Research, NIHHS, RDA, Eumseong, 369-873, Korea;(4) College of Pharmacy, Chungbuk National University, Cheongju, 361-763, Korea |
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| Abstract: | A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 μM. |
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| Keywords: | Callistemon lanceolatus Myrtaceae Triterpenoids Betulinic acid 3-O-caffeate NO production inhibitor |
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