Serum interleukin-6 levels in response to biologic treatment in patients with psoriasis |
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Authors: | Shinnosuke Muramatsu Ryoji Kubo Emi Nishida |
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Institution: | Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan |
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Abstract: | Objectives: Psoriasis is a chronic autoimmune disease involving a complex network of cytokines such as interleukin (IL)-6. We tested the hypothesis that serum IL-6 level is a useful indicator of disease activity and predicts the treatment response to biologics in patients with psoriasis.Methods: We analyzed 113 psoriasis patients treated with biologics (73 with infliximab IFX], 24 with adalimumab ADA], and 16 with ustekinumab UST]) in our hospital. Disease severity was assessed using the Psoriasis Area and Severity Index (PASI) score, and Disease Activity Score 28 based on C-reactive protein (DAS28-CRP).Results: Before treatment, serum IL-6 levels significantly correlated with PASI scores in patients with psoriasis vulgaris (r?=?0.432, p?=?0.001) and with DAS28-CRP in patients with psoriatic arthritis (r?=?0.469, p?=?0.010). Serum IL-6 levels were significantly decreased by IFX (from 4.8 to 1.5) and ADA (from 2.5 to 1.4) therapy. In psoriatic arthritis, serum IL-6 levels at the endpoint tended to be lower in patients who achieved DAS28-CRP <2.3 (European League Against Rheumatism remission criteria) than in patients who did not.Conclusion: Serum IL-6 level may be a useful biomarker for assessing disease activity in patients with psoriasis and for predicting responsiveness of joint symptoms to biologic treatment. |
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Keywords: | Adalimumab Infliximab Interleukin-6 Psoriasis Ustekinumab |
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