| The Effect of Benzyltetrahydropalmatine (BTHP) on Action Potentials and the Two Components of Delayed Rectifying Potassium Currents in Guinea Pig Ventricular Myocytes |
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| 作者姓名： | 阎升 李新华 姚伟星 夏国瑾 江明性 黄文龙 黄枕亚 彭司勋 |
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| 作者单位： | 同济医科大学药理教研室，中国药科大学药化研究室 |
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| 摘 要： | 苄基四氢巴马汀为四氢巴马汀的衍化物，本文采用标准膜片钳全细胞记录技术，研究了苄基四氢巴马汀对豚鼠心室肌单细胞动作电位及延迟整流钾通道（Ｉｋ）两种成分（Ｉｋｓ和Ｉｋｒ）的选择性作用。结果表明：（１）３０μｍｏｌ·Ｌ－１苄基四氢巴马汀可显著延长无钙细胞外液条件下动作电位的ＡＰＤ９０（从１４３±１６ｍｓ到１８４±２１ｍｓ，Ｐ＜００１，ｎ＝５），而对ＲＰ，ＡＰＡ无明显影响，其对ＡＰＤ９０的延长作用不依赖于胞外钙。（２）苄基四氢巴马汀对延迟整流钾通道两种成分均有不同程度的阻滞作用，其阻滞Ｉｋｒ的ＩＣ５０（半数抑制浓度）为７９μｍｏｌ·Ｌ－１，阻滞Ｉｋｓ的ＩＣ５０为２２４μｍｏｌ·Ｌ－１，可见苄基四氢巴马汀对Ｉｋ的阻滞作用无选择性
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| 关 键 词： | 苄基四氢巴马汀 膜片钳技术 延迟整流钾电流 心室肌细胞 |
The Effect of Benzyltetrahydropalmatine (BTHP) on Action Potentials and the Two Components of Delayed Rectifying Potassium Currents in Guinea Pig Ventricular Myocytes * |
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| Sheng Yan ,Xin Hua Li ,Wei Xing Yao ,Guo Jin Xia ,Ming Xing Jiang ,Wen Long Huang ,Zhen Ya Huang and Si Xun Peng.The Effect of Benzyltetrahydropalmatine (BTHP) on Action Potentials and the Two Components of Delayed Rectifying Potassium Currents in Guinea Pig Ventricular Myocytes[J].Journal of Chinese Pharmaceutical Sciences,1998(4). |
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| Authors: | Sheng Yan Xin Hua Li Wei Xing Yao Guo Jin Xia Ming Xing Jiang Wen Long Huang Zhen Ya Huang and Si Xun Peng |
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| Institution: | Sheng Yan 1,Xin Hua Li 1,Wei Xing Yao 1,Guo Jin Xia 1,Ming Xing Jiang 1,Wen Long Huang 2,Zhen Ya Huang 2 and Si Xun Peng 21. Department of Pharmacology,Tongji Medical University,Wuhan 430030, 2. Division of Medical Chemistry,Chi |
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| Abstract: | |
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| Keywords: | Benzyltetrahydropalmatine Patch clamp technique Delayed rectifier potassium channel Ventricular myocytes |
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