Progressive change in lymphocyte distribution and degree of hypergammaglobulinemia with age in children with hemophilia |
| |
Authors: | B T Shannon J Roach M Cheek-luten C Orosz F B Ruymann |
| |
Institution: | (1) Departments of Pediatrics and Pathology, Ohio State University School of Medicine, Children's Hospital, 43205 Columbus, Ohio;(2) Department of Pediatrics, Ohio State University School of Medicine, Children's Hospital, 43205 Columbus, Ohio;(3) Department of Surgery, Ohio State University School of Medicine, 43210 Columbus, Ohio |
| |
Abstract: | Fifty asymptomatic, pediatric hemophiliacs were examined for distribution of T-cell subsets, responsiveness to mitogen stimulation, interleukin-2 production, hypergammaglobulinemia, and the presence of antibody to virus including the human T-lymphotrophic virus type III (HTLV-III). Hemophilia A patients receiving factor VIII concentrate as replacement therapy had the most pronounced changes including decreased T4/T8 ratios and lowerin vitro responsiveness to both phytohemagglutinin and pokeweed mitogen. Hemophilia A patients treated with cryoprecipitate and hemophilia B patients did not demonstrate these changes. Regardless of replacement therapy, hemophiliacs demonstrated a progressive decrease in the T4/T8 ratio and a progressive increase in the degree of IgG hypergammaglobulinemia as they aged. The amount of factor or cryoprecipitate or exposure to virus did not influence the T4/T8 ratio. These changes appear to be a result of chronic product exposure, which becomes more pronounced with increasing age. |
| |
Keywords: | T subsets hemophilia A hemophilia B flow cytometry human T-lymphotropic virus type III |
本文献已被 SpringerLink 等数据库收录! |
|