| 左卡尼汀对心肺复苏后大鼠肾脏保护作用的实验研究 |
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| 引用本文： | 陈达,崔斌,王斯闻,王绍久,朱杰.左卡尼汀对心肺复苏后大鼠肾脏保护作用的实验研究[J].中国误诊学杂志,2011,11(33):8077-8079. |
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| 作者姓名： | 陈达 崔斌 王斯闻 王绍久 朱杰 |
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| 作者单位： | 1. 中国医科大学附属第四医院急诊科,辽宁沈阳,110032
2. 解放军第201医院急诊科,辽宁辽阳,111000 |
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| 基金项目： | 辽宁省科学技术基金(2009225040) |
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| 摘 要： | 目的 通过观察左卡尼汀对复苏后大鼠血清、肾组织中细胞因子的影响,探讨左卡尼汀对复苏后肾脏保护作用的机制.方法 建立心肺复苏大鼠模型,30只Wistar大鼠随机分为手术对照组(S组)、常规复苏组(C组)和左卡尼汀组(L组),每组10只,S组只行手术操作,不致颤；C组造成心搏骤停并行常规复苏；L组在心搏骤停并复苏成功后静脉注射左卡尼汀.动态观察,血清中TNF-α、IL-1β、iNOS、SU、Scr及肾组织中TNF-α、IL-1β、iNOS的变化.结果 与S组比较,C组和L组复苏成功后血清TNF-α、IL-1β、iNOS、SU、Scr及肾组织TNF-α、IL-1β、iNOS有不同程度升高(P＜0.01).L组与同时相C组比较,血清TNF-α、IL-1β、iNOS、SU、Scr及肾组织TNF-α、IL-1β、iN-OS升高程度减轻(P＜0.05).结论 左卡尼汀能减轻炎性细胞因子介导的肾脏损伤,对复苏后肾脏有保护作用.
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| 关 键 词： | 肉碱/药理学 心肺复苏术 肾/药物作用 疾病模型 动物 |
Protective effects of levocarnitine on kidney after cardiopulmonary resuscitation in rat |
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| CHEN Da,CUI Bin,WANG Si-wen,WANG Shao-jiu,ZHU Jie.Protective effects of levocarnitine on kidney after cardiopulmonary resuscitation in rat[J].Chinese Journal of Misdiagnostics,2011,11(33):8077-8079. |
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| Authors: | CHEN Da CUI Bin WANG Si-wen WANG Shao-jiu ZHU Jie |
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| Institution: | CHEN Da,CUI Bin,WANG Si-wen,WANG Shao-jiu,ZHU Jie Department of Emergency,The Fourth Affiliated Hospital of China Medical Uinversity,Shenyang 110032,China |
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| Abstract: | Objective To investigate the change of cytokines induced by cardiopulmonary resuscitation after cardiac arrest and the mechanism of protective effects of levocarnitine.Methods After setting up cardiopulmonary resuscitation model in rats,30 anmials were randomly devided into operation control group(group S,n=10),routine resuscitation group(group C,n=10) and levocarnitine treated group(group L,n=10).Group S was not induced cardiac arrest.Group C was performed standard CPR after cardiac arrest.Group L was trea... |
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| Keywords: | Carnitine/pharmacology Cardiopulmonary Resuscitation Kidney/drug effects Disease Models Animal |
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