肟菌酯原药致突变毒性研究

目的 探讨肟菌酯的致突变性,预测其遗传危害和潜在致癌作用. 方法 分别按照GB15670-1995《农药登记毒理学试验方法》、GB/T 21793-2008《化学品体外哺乳动物细胞基因突变试验方法》、GB/T 21794-2008《化学品体外哺乳动物细胞染色体畸变试验方法》进行试验. 结果 微核试验、体外哺乳动物细胞染色体畸变试验和体外哺乳动物TK基因突变试验结果显示,肟菌酯原药各剂量组与溶剂对照组比较,差异无统计学意义（P＞0.05）;Ames试验结果显示各菌株的各测试浓度的回复突变菌落数均未超过自发回复突变菌落数的2倍. 结论 在本试验条件下,肟菌酯原药无致突变性.

Study on Mutagenicity of Trifloxystrobin TC

Objective To explore the mutagenicity of trifloxystrobin TC,and study its genetic hazard and potential carcinogenesis.Methods The test was conducted in compliance with ＂Toxicological Test Methods of Pesticides for Registration＂ （GB15670-1995）,＂Chemicals-Test Method of in Vitro Mammalian Cell Gene Mutation＂ （GB/T 21793-2008）,and ＂Chemicals-Test Method of in Vitro Mammalian Chromosome Aberration＂ （GB/T 21794-2008）.Results Mice bone marrow cell micronucleus test,in vitro mammalian cell gene mutation test and in vitro mammalian chromosome aberration test showed that each dosage group showed no statistically significant difference in comparison with the solvent control group （P ＞0.05）.Ames test showed that there was no reproducible increase at the three test concentrations in the number of revertant colonies per plate among the test strains.Conclusion Trifloxystrobin TC shows no obvious mutagenicity under this experimental condition.