| 慢性湿疹小鼠模型的建立 |
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| 引用本文： | 刘丹,赵梓纲,焦泽龙,冯峥,李恒进.慢性湿疹小鼠模型的建立[J].军事医学科学院院刊,2011,35(4):290-292. |
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| 作者姓名： | 刘丹 赵梓纲 焦泽龙 冯峥 李恒进 |
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| 作者单位： | 解放军总医院皮肤科,北京,100853 |
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| 摘 要： | 目的建立小鼠背部慢性湿疹模型。方法用0.5%、1.0%和2.0%3个不同浓度的2,4二-硝基氯苯（DNCB）反复刺激小鼠背部皮肤,比较不同浓度DNCB刺激局部皮肤产生的皮损炎症程度及组织病理切片炎症细胞数量的差异。结果小鼠背部皮损炎症程度及组织病理炎症细胞数量各组间均有统计学意义。结论 0.5%DNCB反复刺激小鼠背部皮肤可建立慢性湿疹模型。
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| 关 键 词： | 模型 动物 慢性湿疹 2 4二-硝基氯苯 病理学 T淋巴细胞 炎症 |
A mouse model of chronic eczema |
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| LIU Dan,ZHAO Zi-gang,JIAO Ze-long,FENG Zheng,LI Heng-jin.A mouse model of chronic eczema[J].Bulletin of the Academy of Military Medical Sciences,2011,35(4):290-292. |
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| Authors: | LIU Dan ZHAO Zi-gang JIAO Ze-long FENG Zheng LI Heng-jin |
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| Institution: | LIU Dan,ZHAO Zi-gang,JIAO Ze-long,FENG Zheng,LI Heng-jin(Department of Dermatology,PLA General Hospital,Beijing 100853,China) |
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| Abstract: | Objective To establish a model of chronic eczema on the dorsum of mice.Methods Dorsum of mice was repeatedly challenged with 0.5%,1.0% and 2.0% DNCB,respectively.The difference in the inflammation degree of lesion and quantity of inflammatory cells in histopathology were compared.Results The distinction of the inflammation degree of lesion and quantity of inflammatory cells in histopathology was of statistical significance(P<0.05) in different groups.Conclusion Repeated challenge with 0.5 % DNCB may induce ... |
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| Keywords: | 2 |
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