辛伐他汀治疗老年高脂血症疗效及安全性研究

目的:观察辛伐他汀治疗高脂血症的疗效和安全性。方法:老年高脂血症患者47例,观察治疗前后血脂变化和相关不良反应。结果:治疗30天、60天后血清总胆固醇(TC)、甘油三酯(TG)均较治疗前显著下降(P<0.01),高密度脂蛋白胆固醇(HDL-C)水平较治疗前显著升高(P<0.01);治疗前后低密度脂蛋白胆固醇(LDL-C)水平比较差异无统计学意义(P>0.05)。治疗后未出现严重不良反应。治疗后患者血糖及肌酐水平较前降低(P<0.01),结论:辛伐他汀治疗高脂血症疗效好,不良反应少,值得在临床推广应用,对患者空腹血糖及肌酐水平的影响还有待进一步研究。

Efficacy and safety of Simvastatin Treatment in the Old Patient with Hyperlipemia

Objecc： Observing the efficacy and safety of Simvastatin treatment in patient with hyperlipemia Method： observing the change of blood fat and the pre-and post-treatment related adverse reactions in 47 cases of the old patient with hyperlipemia,Result： the TC and TG After 30 days,60 days were higher than befor treatment（P〈0.01）,HDL-C was higher than before treatment（P〉0.05）;it was not statistic significance between the pre-and after-treatment LDC-C（P〉0.05）;there was not the sever adverse reactions after treatment.The blood glucose and creatinine in patients were lower than before treatment（P〈0.01）;Conclusion： There was good efficacy of Simvastatin in hyperlipemia,which was little adverse reactions,and worthy of popularization and application,whose effect is worth of researching more the blood glucose and creatinine in patients with hyperlipemia.