Combined treatment of psoriasis with etretinate plus hydroxyurea

Nineteen patients with extensive, therapy-resistant psoriasis received combined treatment with etretinate plus hydroxyurea. The individual components were given at a reduced dosage and hydroxyurea was administered intermittently. During 12 weeks of treatment, complete remission or marked improvement was observed in 16 patients (84%). The combination of etretinate and hydroxyurea in the above-mentioned regimen was both effective and well-tolerated.