江门市2001～2003年麻疹免疫水平监测分析

目的评价江门市麻疹疫苗(MV)基础免疫的效果及健康人群抗体水平。方法(1)对应该接受基础免疫的健康儿童按常规进行麻疹疫苗接种,并在免疫前和免疫后一个月内分别抽取外周血进行麻疹抗体检测;(2)对江门市部分健康人群抽取外周血进行麻疹抗体检测。结果(1)2001～2003年基础免疫前健康儿童麻疹抗体阳性率分别为19.05%、17.57%和24.05%,麻疹抗体几何平均滴度倒数(GMRT)分别为3.38、2.93和3.06;基础免疫后一个月麻疹抗体阳性率分别为98.26%、97.30%和96.20%,GMRT分别为465.59、803.53和578.10;(2)健康人群的麻疹抗体阳性率为93.47%,GMRT为687.07,各年龄组之间抗体阳性率差异无显著性。结论江门市麻疹整体初免抗体水平较高,基础免疫是预防控制麻疹流行的重要手段。

Monitoring and Analysis on the Level of Measles Immunization from 2001 to 2003 in Jiangmen City

Objective This research was conducted to assess the basic immunization effectiveness of measles vaccine (MV) and the level of antibodies in healthy population in Jiangmen city. Methods (1).Conventional MV vaccination was employed for healthy children who should have been subject to basic immunization. Peripheral blood was drawn within one month before and after immunization to determine measles antibodies; (2). For part of healthy population in this city, peripheral blood was collected for testing of measles antibodies. Results (1). From 2001 to 2003, the positive rate of antibodies in healthy children was 19.05%, 17.57% and 24.05%, and the geometric mean reverse titer (GMRT) of measles antibodies was 3.38, 2.93 and 3.06 respectively before basic immunization; One month after basic immunization was administered, the rate was 98.26%, 97.30% and 96.20%, and GMRT was 465.59, 803.53 and 578.10 ,respectively; (2) For healthy populations, the positive rate of measles antibodies was 93.47% and GMRT was 687.07, showing no significant difference among each age group as for positive antibody rate. Conclusion The overall antibody level of measles for first immunization in Jiangmen is relatively high and basic immunization is an important approach to prevent and control the epidemic of measles.