非病毒基因递送载体的研究进展

目前,基因药物的递送成为药学研究的热点,基因递送载体主要包括病毒载体和非病毒载体。非病毒基因载体的毒性低,生物相容性好,转染效率高,具有潜在的临床应用价值。本文就靶向递送基因载体、多功能基因载体、同时载基因与化疗药物的载体、智能基因载体和脂质体等非病毒基因递送载体的研究进展做一综述。

Advances in research on non-viral vectors for gene delivery

Currently,the delivery of gene drugs has become the hot point of pharmaceutical research. Viral and non-viral vectors are the two major vehicles for gene delivery. Non-viral vectors have the advantages of low toxicity,good biocompatihility and high efficiency of transfection, showing great potential for clinical use. Advances in research on non-viral vectors, such as targeting gene vectors,muhifunetional gene vectors, intelligent gene vectors, gene vectors which simultaneously carry chemo- therapeutic drugs, and liposome gene vectors are reviewed in this paper.