银屑病发病机制的免疫学研究进展

银屑病是多基因遗传背景下的免疫性疾病,与T细胞、树突状细胞等多种免疫细胞以及血管内皮生长因子等多种细胞因子有关,发病机制复杂,病因尚不明确。银屑病的组织病理学表现为角质形成细胞过度增生、炎症细胞聚集和真皮乳头部血管增生扩张,其皮损中多种细胞因子表达增加。本文就银屑病发病机制的免疫学研究进展作一综述。

Research progress in immunopathogenesis of psoriasis

Psoriasis is an immunological disease dominated by polygenes. Its pathogenesis is complicated, unclear, and associated with vascular endothelial growth factor（VEGF） as well as many immune cells such as T cells and dentric cells. The most specific histopathological changes that distinguish psoriasis from other inflammatory skin diseases are excessive hyper- plasia of keratinocyte,aggregation of inflammatory cells and dermopapillary vascularization and expansion. Research progress in immunopathogenesis of psoriasis is reviewed in the paper.