乳腺癌钼靶X线表现与分子生物学表达的相关性研究

目的探讨乳腺癌钼靶X线表现与癌细胞雌激素受体（ER）、孕激素受体（PR）及人体抑癌基因（P53）生物学相关性,旨在为乳腺癌的早期诊断及预测预后提供依据。方法回顾性分析经手术病理证实的152例乳腺浸润性导管癌患者为研究对象。患者均于术前行钼靶X线检查,重点观察病变肿块、钙化、结构紊乱、局部密度增高等。以病理组织学结果做对照。术后标本测定ER、PR、P53的表达情况,分析其与钼靶X线表现间的关系。结果 152例浸润性导管癌中,表现为肿块伴毛刺或形态不规则与ER、PR表达关联（χ2=8.108,P〈0.05;χ2=5.571,P〈0.05）;有钙化与ER、PR表达有统计学差异（χ2=4.851,P〈0.05;χ2=4.579,P〈0.05）;乳腺结构紊乱或局部密度增高与ER、PR表达差异有统计学意义（χ2=6.521,P〈0.05;χ2=5.602,P〈0.05）;乳腺结构紊乱或局部密度增高与P53表达有统计学差异（χ2=7.883,P〈0.05）。结论乳腺癌的一些重要钼靶X线征象与ER、PR、P53之间存在一定相关性,在一定程度上反映了乳腺癌细胞的生物学行为和预后,为临床早期诊断和治疗提供更多客观依据。

Breast cancer mammography X-ray findings with the expression of molecular biology research

Objective Biology explore breast cancer mammography X-ray findings with the cancer cells of the estrogen receptor（ER） and progesterone receptor（PR） and human tumor suppressor gene（P53）, aimed at early diagnosis and prognosis of brdast provide the basis. Methods A retrospective analysis of 152 patients with pathologically proved infiltrating ductal breast cancer study. The patients preoperative mammography X-ray examination focus observed increased lesion mass, calcification, structural disorder, local density. To histopathological results do control. Postoperative specimens Determination ER, PR, P53 expression analysis of the relationship between them with X-ray mammography performance. Results 152 cases of invasive ductal carcinoma, showed a mass with irregular burrs or form associated with the expression of ER, PR（x2=8.108, P〈0.05; x^2=5.571, P〈0.05）; Calcification significant difference in expression of ER, PR（x^2=4.851, P〈0.05; x^2=4.579, P〈0.05）; Increased breast structural disorder or local density and ER, PR expression difference was statistically significant（x^2=6.521, P〈0.05, x^2=5.602, P〈0.05）. Breast structural disorder or increased local density and P53 expression significant difference（x^2=7.883, P〈0.05）. Conclusion Breast cancer mammography X-ray findings exists a certain correlation between ER, PR, P53, to some extent, reflect the biological behavior and prognosis of breast cancer cells, to provide more for the early diagnosis and treatment objective basis.