108例泌尿系感染真菌分布及耐药性分析

目的:分析感染真菌的菌株分布及耐药性,为临床合理选择用抗真菌药物提供依据。方法:回顾性分析微生物实验室中段尿培养结果,对真菌培养和药敏试验结果进行归纳总结。结果:①真菌培养结果:共分离出108株真菌,其中白色念珠菌为39株(36.11%),其次为近平滑念珠菌29株(26.86%),热带念珠菌22株(20.37%);②药敏试验结果:真菌对两性霉素B、5-氟胞嘧啶、伏立康唑、氯康唑、伊曲康唑的耐药率分别为2.78%、6.48%、30.56%、37.04%、43.52%。结论:检出的真菌中以白色念珠菌检出率最高,说明其为临床真菌感染的主要致病菌;检出的真菌对两性霉素B、5-氟胞嘧啶的耐药率较低,但是对伏立康唑、氯康唑、伊曲康唑的耐药率较高。

Distribution and drug resistance of 108 funged strains causing urinary tract infections

Objective To analyze the distribution and resistance characteristic of fungus isolated from the culture of midstream urine,in order to provide evidence for reasonable selection of antibiotics.Method The fungus isolated of midstream urine culture were identified and antibiotic resistance analyzed in Hainan Provincial People′s Hospital from Aug 2010 to Nov 2011.Results 1.Fungal culture results:A total of 108 strains were isolated,predominantly were C.albicans,accounted for 39 strains(36.11%);29 were C.lusitaniae,accounted for 26.86% and 22 were C.tropicalis,accounted for 20.37%.2:The results of drug sensitivity test:The resistant rate to amphotericin B,5-fluorocytosine,voriconazole,fluconazole and itraconazole were 2.78%,6.48%,30.56%,37.04% and 43.52%,respectively.Conclusion C.albicans had the highest detection rate,and were the major pathogen of fungal infection.The tested epiphytes had slighter resistance to amphotericin B and 5-fluorocytosine,higher resistance to voriconazole,fluconazole and itraconazole.