COVID-19 risk in breast cancer patients receiving CDK4/6 inhibitors: literature data and a monocentric experience |
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Authors: | Maddalena Barba MD Eriseld Krasniqi MD Laura Pizzuti MD Marco Mazzotta MD Daniele Marinelli MD Greta Giuliano MD Francesca Sofia Di Liso MD Federico Cappuzzo MD Lorenza Landi MD Silverio Tomao MD Gennaro Ciliberto MD Patrizia Vici MD |
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Institution: | 1. Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy;2. Medical Oncology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University, Rome, Italy;3. Department of Radiological, Oncological and Anatomo-Pathological Sciences, Policlinico Umberto I, Sapienza – Università di Roma, Rome, Italy;4. Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy |
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Abstract: | Substantial changes in the management of cancer patients have been required worldwide in response to the COVID-19 pandemic. Beyond the due details on the primitive cancer site and setting at diagnosis, these latter adaptions are most commonly exemplified by a significant reduction in the screening of asymptomatic subjects, delays in elective surgery and radiotherapy for primary tumors, and dose reductions and/or delays in systemic therapy administration. Advanced breast cancer patients with hormonal receptor positive, HER2 negative tumors are usually treated with endocrine therapy combined with CDK 4/6 inhibitors as first- and second-line treatment. During the pandemic, experts’ recommendations have suggested the omission or delay of CDK 4/6 inhibitors delivery, or a careful evaluation of their real need due to the hypothesized increased risk of SARS-Cov-2 infection and disease possibly related to neutropenia. The inherent literature is sparse and inconsistent. We herein present data on the use of CDK 4/6 inhibitors during the pandemic. The evidence reported punctually reflects the experience matured at our Institution, a comprehensive cancer centre, on the topic of interest. |
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Keywords: | CDK4/6 inhibitors Covid-19 HR positive/HER2 negative metastatic breast cancer |
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