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Development and evolution of the vestibular apparatuses of the inner ear
Authors:Kacey Mackowetzky  Kevin H. Yoon  Emily J. Mackowetzky  Andrew J. Waskiewicz
Affiliation:Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
Abstract:The vertebrate inner ear is a labyrinthine sensory organ responsible for perceiving sound and body motion. While a great deal of research has been invested in understanding the auditory system, a growing body of work has begun to delineate the complex developmental program behind the apparatuses of the inner ear involved with vestibular function. These animal studies have helped identify genes involved in inner ear development and model syndromes known to include vestibular dysfunction, paving the way for generating treatments for people suffering from these disorders. This review will provide an overview of known inner ear anatomy and function and summarize the exciting discoveries behind inner ear development and the evolution of its vestibular apparatuses.
Keywords:balance  inner ear  otocysts  otoliths  saccule  semi-circular canals  signaling pathways  utricle  vertigo  vestibular apparatus  vestibular system  vestibulocochlear nerve
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